Penance

damage is prevented — 568 cards in the game can cause this (Penance is one).

When a permanent has damage prevented thanks to Penance:

1. Phyrexian Vindicator — deals that much damage
2. Selfless Squire — puts that many +1/+1 counters on itself
3. New Way Forward — deals that much damage
4. Samite Ministration — gains you that much life
5. Judgment of Alexander — deals its power damage

an enchantment is cast — 3,673 cards in the game can cause this (Penance is one).

When Penance is cast:

1. Hallowed Haunting — makes a token
2. Daxos the Returned — puts a counter on a permanent
3. Tatsunari, Toad Rider — makes a token
4. Sythis, Harvest's Hand — gains you 1 life
5. Sigil of the Empty Throne — makes a token
6. Dawnhart Geist — gains you 2 life
7. Herald of the Pantheon — gains you 1 life
8. Kami of Transience — puts a +1/+1 counter on itself
9. Argothian Enchantress — draws you 1 card
10. Mesa Enchantress — draws you 1 card

255 other cards care about it too. These are the ones with the most connections.

a nontoken enchantment enters the battlefield — 3,691 cards in the game can cause this (Penance is one).

1. Historian's Boon — When Penance enters, Historian's Boon makes a token

an enchantment enters the battlefield — 3,743 cards in the game can cause this (Penance is one).

1. Calix, Guided by Fate — When Penance enters, Calix, Guided by Fate puts a counter on a creature
2. Elvish Archivist — When Penance enters, Elvish Archivist draws you 1 card
3. Victor, Valgavoth's Seneschal — When Penance enters, Victor, Valgavoth's Seneschal surveils
4. Strength from the Fallen — When Penance enters, Strength from the Fallen gives +X/+X, where X is the number of creature cards in your graveyard
5. Doomwake Giant — When Penance enters, Doomwake Giant shrinks a creature by -1/-1
6. Cacophony Unleashed — When Penance enters, Cacophony Unleashed turns something into a creature
7. Ghostly Dancers — When Penance enters, Ghostly Dancers makes a token
8. Thassa's Devourer — When Penance enters, Thassa's Devourer mills a card
9. Killian, Decisive Mentor — When Penance enters, Killian, Decisive Mentor taps a creature
10. Thoughtrender Lamia — When Penance enters, Thoughtrender Lamia makes an opponent discard a card

58 other cards care about it too. These are the ones with the most connections.