Simulacrum

life is gained — 2,076 cards in the game can cause this (Simulacrum is one).

When Simulacrum gains life:

1. Dina, Soul Steeper — makes each opponent lose 1 life
2. Marina Vendrell's Grimoire — draws you that many cards
3. South Wind Avatar — makes each opponent lose 1 life
4. Rodolf Duskbringer — grants indestructible
5. Fiendish Panda — puts a +1/+1 counter on itself
6. Veinwitch Coven — brings a card back
7. Cleric Class — puts a counter on a creature
8. Lich's Mastery — draws you that many cards
9. Wall of Limbs — puts a +1/+1 counter on itself
10. Ratchet, Field Medic // Ratchet, Rescue Racer — triggers

84 other cards care about it too. These are the ones with the most connections.

anything deals noncombat damage — 3,068 cards in the game can cause this (Simulacrum is one).

When Simulacrum deals noncombat damage:

1. Quest for Pure Flame — puts a quest counter on itself
2. Fear of Burning Alive — deals that amount damage
3. Niv-Mizzet, Visionary — draws you that many cards
4. Chandra's Incinerator — deals that much damage
5. Chandra's Pyreling — gets +1/+0
6. Talon of Pain — puts a charge counter on itself
7. Asgardian Inspiration — returns itself from the graveyard
8. Thor, Guardian of Midgard — exiles a card from your library
9. Virtue of Courage // Embereth Blaze — exiles a card from your library

37 other cards care about it too. These are the ones with the most connections.

an instant is cast — 3,931 cards in the game can cause this (Simulacrum is one).

When Simulacrum is cast:

1. Soul-Scar Mage — gets +1/+1
2. Tomik, Izzet Sparkmage — gets +1/+1
3. Tor Wauki the Younger — deals 2 damage
4. Lunar Mystic — draws you 1 card
5. Ojer Pakpatiq, Deepest Epoch // Temple of Cyclical Time — grants rebound
6. Repeated Reverberation — copies an ability
7. Bill Potts — copies an ability
8. Riku of Two Reflections — copies a spell
9. Artist's Talent — draws and discards
10. In the Eye of Chaos — counters a spell

427 other cards care about it too. These are the ones with the most connections.

a creature is dealt damage — 18,923 cards in the game can cause this (Simulacrum is one).

When a creature is dealt damage thanks to Simulacrum:

1. Soul Link — gains you that much life
2. Shriveling Rot — kills it
3. Cryoshatter — kills a creature
4. Hot Soup — kills a creature
5. Cracked Skull — kills a creature
6. Sporogenic Infection — kills a creature
7. Frozen Solid — kills a creature
8. Mortal Wound — kills a creature
9. Mire Blight — kills it
10. Death Pits of Rath — kills it

17 other cards care about it too. These are the ones with the most connections.

anything is cast — 31,128 cards in the game can cause this (Simulacrum is one).

When Simulacrum is cast:

1. Windrider Wizard — draws you 1 card
2. Relic Amulet — puts a charge counter on itself
3. Rockslide Sorcerer — deals 1 damage
4. Umara Wizard // Umara Skyfalls — grants flying
5. Alania, Divergent Storm — makes an opponent draw 1 card
6. Umara Mystic — gets +2/+0
7. Master of Winds — triggers

5 other cards care about it too. These are the ones with the most connections.