Apple of Eden, Isu Relic

an artifact is sacrificed — 761 cards in the game can cause this (Apple of Eden is one).

When you sacrifice Apple of Eden, Isu Relic:

1. Megatron, Tyrant // Megatron, Destructive Force — deals the sacrificed artifact's mana value damage
2. Moonstone Eulogist — puts a +1/+1 counter on itself
3. Magnetic Snuffler — puts a +1/+1 counter on itself
4. Gleaming Geardrake — puts a +1/+1 counter on itself
5. Esoteric Duplicator — makes a token
6. Biotech Specialist — deals 2 damage
7. Jaws, Relentless Predator — deals 1 damage
8. Crime Novelist — puts a +1/+1 counter on itself

6 other cards care about it too. These are the ones with the most connections.

an artifact in a graveyard — 1,226 cards in the game can cause this (Apple of Eden is one).

When Apple of Eden, Isu Relic is in the graveyard:

1. Loran, Disciple of History — can bring it back
2. The Emperor of Palamecia // The Lord Master of Hell — gets bigger
3. Builder's Talent — can bring it back
4. Trading Post — can bring it back
5. Tasigur, the Golden Fang — can bring it back
6. Serpent of the Pass — gets bigger
7. Emeria Shepherd — can bring it back
8. Goblin Engineer — can bring it back
9. Daretti, Rocketeer Engineer — can bring it back
10. Scrap Welder — can bring it back

179 other cards care about it too. These are the ones with the most connections.

a nontoken artifact is put into a graveyard from the battlefield — 1,226 cards in the game can cause this (Apple of Eden is one).

When Apple of Eden, Isu Relic is put into a graveyard from the battlefield:

1. Pia's Revolution — deals 3 damage
2. Farid, Enterprising Salvager — makes a token
3. Psychomancer — makes each opponent lose 1 life
4. Sly Requisitioner — makes a token
5. Slagstone Refinery — makes a token
6. Ratchet, Field Medic // Ratchet, Rescue Racer — triggers

1 other card cares about it too. These are the ones with the most connections.

an artifact goes to a graveyard — 1,250 cards in the game can cause this (Apple of Eden is one).

When Apple of Eden, Isu Relic hits the graveyard:

1. Ultron the Annihilator — makes each opponent lose 1 life
2. Ultron's Auxiliary — puts a +1/+1 counter on itself

an artifact is put into a graveyard from the battlefield — 1,254 cards in the game can cause this (Apple of Eden is one).

When Apple of Eden, Isu Relic is put into a graveyard from the battlefield:

1. Tezzeret's Touch — brings a card back
2. Krenko, Baron of Tin Street — makes a token
3. Syr Ginger, the Meal Ender — puts a +1/+1 counter on itself
4. Shard of the Void Dragon — puts 2 +1/+1 counters on itself
5. Ich-Tekik, Salvage Splicer — puts a +1/+1 counter on itself
6. Gremlin Infestation — makes a token
7. Summoning Station — untaps itself
8. Marionette Master — makes each opponent lose life equal to this creature's power
9. Fangren Marauder — gains you 5 life
10. Disciple of the Vault — makes each opponent lose 1 life

32 other cards care about it too. These are the ones with the most connections.

an artifact leaves the battlefield — 1,680 cards in the game can cause this (Apple of Eden is one).

1. Sludge Strider — When Apple of Eden, Isu Relic leaves the battlefield, Sludge Strider makes a player lose 1 life

anything is exiled — 2,497 cards in the game can cause this (Apple of Eden is one).

1. The War Doctor — When a permanent is exiled thanks to Apple of Eden, Isu Relic, The War Doctor puts a time counter on itself

life is lost — 3,160 cards in the game can cause this (Apple of Eden is one).

When Apple of Eden, Isu Relic makes a player lose life:

1. The Master of Lake-town — mills a card
2. Intermediate Chirography — puts a counter on a creature
3. Vilis, Broker of Blood — draws you that many cards
4. Vengeful Warchief — puts a +1/+1 counter on itself
5. Wax-Wane Witness — gets +1/+0
6. Oath of Lim-Dûl — sacrifices an enchantment
7. Marina Vendrell's Grimoire — triggers
8. Lich's Mastery — triggers
9. Lich's Tomb — sacrifices a permanent
10. Gonti's Machinations — puts a counter on a permanent you control

46 other cards care about it too. These are the ones with the most connections.

anything is sacrificed — 3,450 cards in the game can cause this (Apple of Eden is one).

1. Gorbag of Minas Morgul — When you sacrifice Apple of Eden, Isu Relic, Gorbag of Minas Morgul triggers

3 other cards care about it too. These are the ones with the most connections.

an artifact is cast — 3,683 cards in the game can cause this (Apple of Eden is one).

When Apple of Eden, Isu Relic is cast:

1. Mendicant Core, Guidelight — copies a spell
2. Death to Our Enemies — makes a token
3. Sai, Master Thopterist — makes a token
4. Ravenous Robots — makes a token
5. Pinnacle Emissary — makes a token
6. Mirrodin Besieged — makes a token
7. Poetic Ingenuity — makes a token
8. Digsite Engineer — makes a token
9. Myrsmith — makes a token

272 other cards care about it too. These are the ones with the most connections.

a card is drawn — 3,815 cards in the game can cause this (Apple of Eden is one).

When Apple of Eden, Isu Relic makes a player draw a card:

1. Toothy, Imaginary Friend — puts a +1/+1 counter on itself
2. Aether Syphon — mills a card

65 other cards care about it too. These are the ones with the most connections.