Archfiend of Despair

hits creature — 2,298 cards in the game can cause this (Archfiend of Despair is one).

1. Jalira, Master Polymorphist — Jalira, Master Polymorphist can put Archfiend of Despair onto the battlefield from your library
2. Kethek, Crucible Goliath — Kethek, Crucible Goliath can put Archfiend of Despair onto the battlefield from your library
3. Polymorph — Polymorph can put Archfiend of Despair onto the battlefield from your library
4. Birthing Ritual — Birthing Ritual can put Archfiend of Despair onto the battlefield from your library
5. Industrial Advancement — Industrial Advancement can put Archfiend of Despair onto the battlefield from your library
6. Killer Instinct — Killer Instinct can put Archfiend of Despair onto the battlefield from your library
7. Arthur, Marigold Knight — Arthur, Marigold Knight can put Archfiend of Despair onto the battlefield from your library
8. Proteus Staff — Proteus Staff can put Archfiend of Despair onto the battlefield from your library
9. Synthetic Destiny — Synthetic Destiny can put Archfiend of Despair onto the battlefield from your library
10. Divergent Transformations — Divergent Transformations can put Archfiend of Despair onto the battlefield from your library

8 other cards care about it too. These are the ones with the most connections.

a Demon enters the battlefield — 284 cards in the game can cause this (Archfiend of Despair is one).

When Archfiend of Despair enters:

1. Blood Speaker — returns itself from the graveyard
2. Be'lakor, the Dark Master — deals its power damage

life is lost — 3,160 cards in the game can cause this (Archfiend of Despair is one).

When a permanent makes a player lose life thanks to Archfiend of Despair:

1. Far Fortune, End Boss — raises your speed
2. Zahur, Glory's Past — raises your speed
3. Mendicant Core, Guidelight — raises your speed
4. Aether Syphon — raises your speed
5. Vnwxt, Verbose Host — raises your speed
6. Embalmed Ascendant — raises your speed
7. Slick Imitator — raises your speed
8. Nesting Bot — raises your speed
9. Howlsquad Heavy — raises your speed
10. Hour of Victory — raises your speed

46 other cards care about it too. These are the ones with the most connections.

anything attacks — 17,934 cards in the game can cause this (Archfiend of Despair is one).

When Archfiend of Despair attacks:

1. Temmet, Naktamun's Will — draws you 1 card
2. Grim Javelineer — gives +1/+0
3. Invisible Woman — triggers
4. Caesar, Legion's Emperor — sacrifices a creature
5. Guide of Souls — triggers
6. Campsite Cuisine — sacrifices a Food
7. Gossip's Talent — triggers
8. Banon, the Returners' Leader — draws and discards
9. Toph, Earthbending Master — puts a counter on a permanent
10. Three Dog, Galaxy News DJ — sacrifices an Aura

111 other cards care about it too. These are the ones with the most connections.

a creature attacks — 17,934 cards in the game can cause this (Archfiend of Despair is one).

When Archfiend of Despair attacks:

1. Adaptive Omnitool — searches a library
2. Anthem of Rakdos — gives +2/+0
3. Kindred Discovery — draws you 1 card
4. Invasion of New Capenna // Holy Frazzle-Cannon — puts counters on a permanent
5. Chorale of the Void — brings a card back
6. Jolene, Plundering Pugilist — makes a token
7. Saw — sacrifices a creature
8. Gisa's Favorite Shovel — makes an opponent sacrifice a creature
9. Ultima Weapon — kills a creature an opponent controls
10. Total War — kills a creature

181 other cards care about it too. These are the ones with the most connections.

a creature blocks — 17,934 cards in the game can cause this (Archfiend of Despair is one).

When Archfiend of Despair blocks:

1. Mage Hunters' Onslaught — makes a player lose 1 life
2. Carnage Gladiator — makes a player lose 1 life
3. Barrow-Blade — strips abilities
4. Heat of Battle — deals 1 damage
5. Tide of War — sacrifices a creature
6. Dead-Iron Sledge — kills a creature
7. Dwindle — kills a creature
8. Shield of the Righteous — triggers

20 other cards care about it too. These are the ones with the most connections.

a nontoken creature attacks — 17,934 cards in the game can cause this (Archfiend of Despair is one).

When Archfiend of Despair attacks:

1. Mardu Ascendancy — makes a token
2. Basri Ket — makes a token
3. Militia's Pride — makes a token

a creature enters the battlefield — 19,800 cards in the game can cause this (Archfiend of Despair is one).

When Archfiend of Despair enters:

1. Slash, Reptile Rampager — deals 2 damage
2. Ray Fillet, Wave Warrior — puts a counter on itself
3. The Neutrinos — gets +1/+0
4. Wingnut, Bat on the Belfry — grants flying, haste and menace
5. Aetherstorm Roc — puts a counter on a permanent you control
6. Raphael, Most Attitude — exiles a card from your library

302 other cards care about it too. These are the ones with the most connections.

anything enters the battlefield — 26,499 cards in the game can cause this (Archfiend of Despair is one).

1. Prowl, Stoic Strategist // Prowl, Pursuit Vehicle — When Archfiend of Despair enters, Prowl, Stoic Strategist // Prowl, Pursuit Vehicle puts a +1/+1 counter on itself

40 other cards care about it too. These are the ones with the most connections.