Circle of Despair

anything leaves the battlefield — 1 card in the game can cause this (Circle of Despair is one).

1. Chainer, Dementia Master — When Chainer, Dementia Master leaves the battlefield thanks to Circle of Despair, it exiles a Nightmare

damage is prevented — 568 cards in the game can cause this (Circle of Despair is one).

When Circle of Despair has damage prevented:

1. Phyrexian Vindicator — deals that much damage
2. Selfless Squire — puts that many +1/+1 counters on itself
3. New Way Forward — deals that much damage
4. Samite Ministration — gains you that much life
5. Judgment of Alexander — deals its power damage

a nontoken creature is sacrificed — 1,714 cards in the game can cause this (Circle of Despair is one).

When you sacrifice a creature to Circle of Despair:

1. Fumulus, the Infestation — makes a token
2. Bag of Devouring — exiles it

a creature is sacrificed — 1,741 cards in the game can cause this (Circle of Despair is one).

When you sacrifice a creature to Circle of Despair:

1. Ziatora, the Incinerator — deals that creature's power damage
2. Dina, Essence Brewer — draws you 1 card
3. Fleshtaker — gains you 1 life
4. Body Dropper — puts a +1/+1 counter on itself
5. Smothering Abomination — draws you 1 card
6. Kels, Fight Fixer — draws you 1 card
7. Caesar, Legion's Emperor — triggers
8. Grist, the Hunger Tide — kills a creature or planeswalker an opponent controls
9. Cabal Therapist — triggers
10. Rakdos, the Muscle — exiles a card from an opponent's library

19 other cards care about it too. These are the ones with the most connections.

a creature in a graveyard — 2,769 cards in the game can cause this (Circle of Despair is one).

Circle of Despair puts cards into the graveyard that:

1. Havengul Lich — can bring back
2. Liliana the Repentant — can bring back
3. Paleoloth — can bring back
4. Chainer, Nightmare Adept — can bring back
5. Banon, the Returners' Leader — can bring back
6. Surgical Suite // Hospital Room — can bring back
7. Sword of Light and Shadow — can bring back
8. Necromantic Thirst — can bring back
9. Krile Baldesion — can bring back
10. Extus, Oriq Overlord // Awaken the Blood Avatar — can bring back

799 other cards care about it too. These are the ones with the most connections.

a nontoken creature dies — 2,769 cards in the game can cause this (Circle of Despair is one).

When you sacrifice a creature to Circle of Despair:

1. Zahur, Glory's Past — makes a token
2. Liesa, Forgotten Archangel — brings a card back
3. Avacyn, Angel of Horror — brings a card back
4. Yedora, Grave Gardener — brings a card back
5. Nim Deathmantle — brings a card back
6. Valkyrie's Call — brings a card back
7. Decaying Soil — brings a card back
8. High-Society Hunter — draws you 1 card
9. Liliana, Heretical Healer // Liliana, Defiant Necromancer — flickers itself
10. Body Launderer — draws and discards

60 other cards care about it too. These are the ones with the most connections.

a creature dies — 2,830 cards in the game can cause this (Circle of Despair is one).

1. Pious Evangel // Wayward Disciple — When you sacrifice a creature to Circle of Despair, Pious Evangel // Wayward Disciple makes each opponent lose 1 life
2. Daxos, Blessed by the Sun — When you sacrifice a creature to Circle of Despair, Daxos, Blessed by the Sun gains you 1 life
3. Elas il-Kor, Sadistic Pilgrim — When you sacrifice a creature to Circle of Despair, Elas il-Kor, Sadistic Pilgrim makes each opponent lose 1 life
4. Shriveling Rot — When you sacrifice a creature to Circle of Despair, Shriveling Rot makes a player lose life equal to its toughness
5. Jeskai Sage — When Jeskai Sage dies thanks to Circle of Despair, it draws you 1 card
6. Meathook Massacre II — When you sacrifice a creature to Circle of Despair, Meathook Massacre II brings a card back
7. Cyclops Superconductor — When Cyclops Superconductor dies thanks to Circle of Despair, it triggers
8. Saffi Eriksdotter — When you sacrifice a creature to Circle of Despair, Saffi Eriksdotter sacrifices itself
9. Treacherous Vampire — When Treacherous Vampire dies thanks to Circle of Despair, it makes you lose life
10. Cavalier of Thorns — When Cavalier of Thorns dies thanks to Circle of Despair, it exiles itself

451 other cards care about it too. These are the ones with the most connections.

a creature goes to a graveyard — 3,011 cards in the game can cause this (Circle of Despair is one).

When a creature hits the graveyard thanks to Circle of Despair:

1. Robot Domination — draws you 1 card
2. Dennick, Pious Apprentice // Dennick, Pious Apparition — triggers
3. Soulcipher Board // Cipherbound Spirit — triggers

11 other cards care about it too. These are the ones with the most connections.

anything is sacrificed — 3,450 cards in the game can cause this (Circle of Despair is one).

1. Gorbag of Minas Morgul — When you sacrifice a creature to Circle of Despair, Gorbag of Minas Morgul triggers

4 other cards care about it too. These are the ones with the most connections.

an enchantment is cast — 3,673 cards in the game can cause this (Circle of Despair is one).

When Circle of Despair is cast:

1. Death to Our Enemies — makes a token
2. Hallowed Haunting — makes a token
3. Daxos the Returned — puts a counter on a permanent

262 other cards care about it too. These are the ones with the most connections.

a creature leaves the battlefield — 4,238 cards in the game can cause this (Circle of Despair is one).

1. Ninja Teen — When you sacrifice a creature to Circle of Despair, Ninja Teen makes each opponent lose 1 life

32 other cards care about it too. These are the ones with the most connections.

a permanent is put into a graveyard from the battlefield — 5,057 cards in the game can cause this (Circle of Despair is one).

1. Gerrard, Weatherlight Hero — When Gerrard, Weatherlight Hero dies thanks to Circle of Despair, it exiles itself

14 other cards care about it too. These are the ones with the most connections.

a card in a graveyard — 7,589 cards in the game can cause this (Circle of Despair is one).

1. Havi, the All-Father — Circle of Despair fills your graveyard toward the 4 or more cards Havi, the All-Father needs
2. Repentant Vampire — Circle of Despair fills your graveyard toward the 7 or more cards Repentant Vampire needs
3. Athreos, Shroud-Veiled — Circle of Despair puts cards into the graveyard that Athreos, Shroud-Veiled can bring back

441 other cards care about it too. These are the ones with the most connections.