Sphere of Annihilation

a planeswalker is exiled — 231 cards in the game can cause this (Sphere of Annihilation is one).

1. Kaya's Ghostform — When a creature is exiled thanks to Sphere of Annihilation, Kaya's Ghostform blinks a permanent

a nontoken artifact is exiled — 334 cards in the game can cause this (Sphere of Annihilation is one).

When Sphere of Annihilation is exiled:

1. Psychomancer — makes each opponent lose 1 life
2. Slagstone Refinery — makes a token

an artifact is exiled — 336 cards in the game can cause this (Sphere of Annihilation is one).

1. Shard of the Void Dragon — When Sphere of Annihilation is exiled, Shard of the Void Dragon puts 2 +1/+1 counters on itself

1 other card cares about it too. These are the ones with the most connections.

a nontoken creature is exiled — 995 cards in the game can cause this (Sphere of Annihilation is one).

1. The War Games — When a creature is exiled thanks to Sphere of Annihilation, The War Games exiles a Warrior

a creature is exiled — 1,003 cards in the game can cause this (Sphere of Annihilation is one).

When a creature is exiled thanks to Sphere of Annihilation:

1. Ashnod's Intervention — brings a card back
2. Syr Vondam, Sunstar Exemplar — puts a +1/+1 counter on itself
3. Kaya, Spirits' Justice — copies a permanent
4. Soulherder — puts a +1/+1 counter on itself

3 other cards care about it too. These are the ones with the most connections.

a creature leaves a graveyard — 1,302 cards in the game can cause this (Sphere of Annihilation is one).

When a creature leaves a graveyard thanks to Sphere of Annihilation:

1. Grim Reaper's Scythe — makes a token
2. Syr Konrad, the Grim — deals 1 damage
3. Cyan, Vengeful Samurai — puts a +1/+1 counter on itself
4. Along the Crooked Way — puts a counter on a Goblin or Army
5. Skeleton Crew — makes a token
6. Desecrated Tomb — makes a token
7. Chalk Outline — makes a token
8. Insidious Roots — makes a token
9. Undead Hand Ninja — makes each opponent lose 1 life
10. Erebos's Titan — triggers

3 other cards care about it too. These are the ones with the most connections.

an artifact leaves the battlefield — 1,680 cards in the game can cause this (Sphere of Annihilation is one).

1. Sludge Strider — When Sphere of Annihilation leaves the battlefield, Sludge Strider makes a player lose 1 life

anything is exiled — 2,497 cards in the game can cause this (Sphere of Annihilation is one).

1. The War Doctor — When Sphere of Annihilation is exiled, The War Doctor puts a time counter on itself

anything leaves a graveyard — 2,503 cards in the game can cause this (Sphere of Annihilation is one).

When a creature or planeswalker leaves a graveyard thanks to Sphere of Annihilation:

1. Blastoneuron — makes each opponent lose 1 life
2. Defiled Crypt // Cadaver Lab — makes a token
3. Teval, the Balanced Scale — makes a token
4. Hologram Stalker — makes a token
5. Tormod, the Desecrator — makes a token
6. Quintorius, Field Historian — makes a token
7. Garrison Excavator — makes a token
8. Amzu, Swarm's Hunger — makes a token
9. Kirol, History Buff // Pack a Punch — becomes prepared
10. Teval's Judgment — triggers

13 other cards care about it too. These are the ones with the most connections.

an artifact is cast — 3,683 cards in the game can cause this (Sphere of Annihilation is one).

When Sphere of Annihilation is cast:

1. Mendicant Core, Guidelight — copies a spell
2. Sai, Master Thopterist — makes a token
3. Ravenous Robots — makes a token
4. Pinnacle Emissary — makes a token
5. Mirrodin Besieged — makes a token
6. Poetic Ingenuity — makes a token
7. Digsite Engineer — makes a token
8. Myrsmith — makes a token
9. Riddlesmith — draws you 1 card
10. Dr. Madison Li — puts a counter on a permanent you control

271 other cards care about it too. These are the ones with the most connections.

a nontoken artifact enters the battlefield — 3,768 cards in the game can cause this (Sphere of Annihilation is one).

When Sphere of Annihilation enters:

1. Ultron, Artificial Malevolence — makes a token
2. The Prydwen, Steel Flagship — makes a token
3. Conquest Mission — puts a quest counter on itself
4. Surge Conductor — proliferates
5. Replication Specialist — makes a token
6. Weapons Manufacturing — makes a token
7. Mirrorworks — makes a token

a nontoken creature leaves the battlefield — 4,133 cards in the game can cause this (Sphere of Annihilation is one).

When a creature leaves the battlefield thanks to Sphere of Annihilation:

1. Tokka & Rahzar, Unsupervised — puts a +1/+1 counter on itself
2. Splinter, the Mentor — makes a token
3. Rat King, Pale Piper — makes a token
4. Dual Nature — exiles a creature

a creature leaves the battlefield — 4,238 cards in the game can cause this (Sphere of Annihilation is one).

1. Lunarch Veteran // Luminous Phantom — When a creature leaves the battlefield thanks to Sphere of Annihilation, Lunarch Veteran // Luminous Phantom gains you 1 life
2. Extractor Demon — When a creature leaves the battlefield thanks to Sphere of Annihilation, Extractor Demon mills a card
3. Aang, Airbending Master — When a creature leaves the battlefield thanks to Sphere of Annihilation, Aang, Airbending Master puts a counter on a permanent
4. Dour Port-Mage — When a creature leaves the battlefield thanks to Sphere of Annihilation, Dour Port-Mage draws you 1 card
5. Vela the Night-Clad — When a creature leaves the battlefield thanks to Sphere of Annihilation, Vela the Night-Clad makes each opponent lose 1 life
6. Phantasmal Mount — When Phantasmal Mount leaves the battlefield thanks to Sphere of Annihilation, it triggers
7. Funeral March — When a creature leaves the battlefield thanks to Sphere of Annihilation, Funeral March makes a player sacrifice a creature
8. Sally Sparrow — When a creature leaves the battlefield thanks to Sphere of Annihilation, Sally Sparrow triggers

21 other cards care about it too. These are the ones with the most connections.